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Glossary

Terms and definitions used in Trial Submission Studio and CDISC standards.

A

ADaM

Analysis Data Model - CDISC standard for analysis-ready datasets derived from SDTM data.

ADSL

ADaM Subject-Level - ADaM dataset containing one record per subject with demographics and key variables.

B

BDS

Basic Data Structure - An ADaM structure used for parameter-based data like vital signs and lab results.

C

CDISC

Clinical Data Interchange Standards Consortium - Organization that develops global data standards for clinical research.

Codelist

A defined set of valid values for a variable. Also known as controlled terminology.

Controlled Terminology (CT)

Standardized sets of terms and codes published by CDISC for use in SDTM and ADaM datasets.

D

Dataset-XML

A CDISC standard XML format for representing tabular clinical data.

Define-XML

An XML standard for describing the structure and content of clinical trial datasets. Required for FDA submissions.

Domain

A logical grouping of SDTM data organized by observation type (e.g., DM for Demographics, AE for Adverse Events).

DM

Demographics - SDTM domain containing one record per subject with demographic information.

E

eCTD

Electronic Common Technical Document - Standard format for regulatory submissions.

F

FDA

Food and Drug Administration - US regulatory agency that requires CDISC standards for drug submissions.

Findings Class

SDTM observation class for collected measurements and test results (e.g., Labs, Vital Signs).

I

ISO 8601

International standard for date and time formats. SDTM uses ISO 8601 format: YYYY-MM-DD.

Interventions Class

SDTM observation class for treatments given to subjects (e.g., Exposure, Concomitant Medications).

M

MedDRA

Medical Dictionary for Regulatory Activities - Standard medical terminology for adverse events.

Metadata

Data that describes other data. In Define-XML, metadata describes dataset structure and variable definitions.

O

ODM

Operational Data Model - CDISC standard for representing clinical data and metadata in XML.

P

PMDA

Pharmaceuticals and Medical Devices Agency - Japanese regulatory agency that requires CDISC standards.

S

SAS Transport (XPT)

File format for SAS datasets used for FDA submissions. See XPT.

SDTM

Study Data Tabulation Model - CDISC standard structure for organizing clinical trial data.

SDTM-IG

SDTM Implementation Guide - Detailed guidance for implementing SDTM, including variable definitions and business rules.

SEND

Standard for Exchange of Nonclinical Data - CDISC standard for nonclinical (animal) study data.

Special Purpose Domain

SDTM domains that don’t fit standard observation classes (e.g., DM, Trial Design domains).

STUDYID

Standard SDTM variable containing the unique study identifier.

U

USUBJID

Unique Subject Identifier - Standard SDTM variable that uniquely identifies each subject across all studies.

V

Variable

An individual data element within a dataset. In SDTM, variables have standard names, labels, and data types.

X

XPT

SAS Transport Format - Binary file format used to transport SAS datasets. Required by FDA for data submissions.

XPT V5

Original SAS Transport format with 8-character variable names.

XPT V8

Extended SAS Transport format supporting 32-character variable names.

Numbers

–DTC Variables

SDTM timing variables containing dates/times in ISO 8601 format (e.g., AESTDTC, VSDTC).

–SEQ Variables

SDTM sequence variables providing unique record identifiers within a domain (e.g., AESEQ, VSSEQ).

–TESTCD Variables

SDTM test code variables in Findings domains (e.g., VSTESTCD, LBTESTCD).